承担科研项目情况：主持并参与科研项目多项，累计可支配经费200余万元，目前主持科研项目两项。 项目一：帕博西尼原料药化学合成工艺的开发，项目来源：横向课题，项目经费160万元。 项目二：帕博西尼新型中试合成研究（编号：20200404111YY），项目来源：吉林省科技厅，项目经费30万元 论文情况：发表SCI十余篇，其中第一作者（含通讯作者）九篇，代表作如下： Studies of Interaction Mechanism between Pyrido [3,4-d] Pyrimidine Inhibitors and Mps1[J].Molecules 2021, 26,5075. 通讯作者。 2D-QSAR study, molecular docking, and moleculardynamics simulation studies of interactionmechanism between inhibitors and transforminggrowth factor-beta receptor I (ALK5)[J].Journal of Biomolecular Structure and Dynamics, 2018 VOL. 36, NO. 14, 3705–3717.通讯作者。 Molecular design and anti-cancer activities of small-molecule monopolar spindle 1 inhibitors: A medicinal chemistry perspective[J].European Journal of Medicinal Chemistry,2019,175:247-268.第三作者。 A chlorogenic acid-loaded hyaluronic acid-based hydrogel facilitates anti-inflammatory and pro-healing effects for diabetic wounds[J].Journal of Drug Delivery Science and Technology Volume 70, April 2022, 103232. 共同一作。 |
